Understanding Your Ovarian Reserve: Why Age and AMH Matter in IVF Success

New Delhi, 03 October, 2024: When couples turn to in-vitro fertilization (IVF) in their journey toward parenthood, one of the first things fertility specialists often evaluate is the woman’s ovarian reserve. Simply put, ovarian reserve refers to the quantity and quality of eggs a woman has left in her ovaries at any given time. Unlike men, who produce new sperm continuously, women are born with a fixed number of eggs that decline with age.

Two of the most significant markers for assessing ovarian reserve are age and Anti-Müllerian Hormone (AMH) levels. These factors not only determine fertility potential but also play a crucial role in predicting IVF outcomes. In this article, we break down what ovarian reserve means, why age and AMH matter, how they are tested, and what couples should know before starting IVF.

What Is Ovarian Reserve?

Ovarian reserve refers to the capacity of a woman’s ovaries to provide healthy eggs that can result in a successful pregnancy. It does not just reflect the number of eggs but also their quality. As women age, both the number and the health of eggs decline, making conception more challenging.

• A woman is born with about 1–2 million eggs.
• By puberty, only about 300,000–400,000 remain.
• Over her reproductive lifetime, only 400–500 eggs will mature and be released during ovulation.

This natural decline means that ovarian reserve is one of the strongest predictors of fertility potential.

Why Age Is a Critical Factor

Age is often called the single most important factor in female fertility. While many women in their late 30s and early 40s conceive naturally, the chances decrease significantly with time.

• Before 30: Egg quality and quantity are usually at their peak.
• 30–35: Fertility gradually begins to decline, though chances of conception remain good.
• 35–37: Fertility drops more noticeably; the risk of chromosomal abnormalities increases.
• After 40: Egg quantity is low, and quality often declines sharply, making natural conception and IVF success more difficult.

Why does age matter so much?

• Older eggs have a higher risk of chromosomal abnormalities, leading to miscarriages or failed IVF cycles.
• The chances of producing healthy embryos decline.
• Ovarian response to fertility medications weakens with age.

Even with advanced IVF technology, success rates are strongly tied to a woman’s age. For example, women under 35 have IVF success rates of around 40–50% per cycle, while for women over 42, the rate may drop to 5–10%.

Understanding AMH: The Fertility Hormone

The Anti-Müllerian Hormone (AMH) is one of the most reliable biomarkers for ovarian reserve. AMH is produced by the small follicles in a woman’s ovaries that contain immature eggs.

• High AMH levels usually indicate a better ovarian reserve (more eggs).
• Low AMH levels suggest a reduced egg supply, which can affect IVF response.

AMH Reference Ranges:

• Above 3.0 ng/mL: High ovarian reserve
• 1.0–3.0 ng/mL: Normal range
• 0.5–1.0 ng/mL: Low reserve
• Below 0.5 ng/mL: Very low reserve

However, AMH is not a measure of egg quality—it only reflects the quantity. A younger woman with low AMH may still have good-quality eggs and a better IVF outcome compared to an older woman with higher AMH but poorer egg quality.

How Ovarian Reserve Is Tested

Several tests are available to evaluate ovarian reserve. Doctors may recommend one or a combination of these before starting IVF:

1. AMH Blood Test – Measures the level of Anti-Müllerian Hormone in the blood. Can be done at any point in the menstrual cycle.
2. Antral Follicle Count (AFC) – An ultrasound scan counts the number of small follicles in the ovaries. A higher count suggests better ovarian reserve.
3. FSH (Follicle-Stimulating Hormone) Test – Done on day 2 or 3 of the menstrual cycle. Higher FSH levels indicate diminished ovarian reserve.
4. Estradiol Test – Measures estrogen levels on day 3; high estradiol can mask high FSH and may suggest poor ovarian reserve.

Ovarian Reserve and IVF Success

For women undergoing IVF, ovarian reserve plays a direct role in:

• Stimulation response – How well the ovaries respond to fertility drugs.
• Number of eggs retrieved – More eggs improve chances of finding healthy embryos.
• Embryo quality – Higher ovarian reserve often correlates with better-quality embryos.
• Success rates – Women with healthy ovarian reserve usually have higher IVF success rates.

Low Ovarian Reserve and IVF

Women with low ovarian reserve are often given higher doses of fertility medication to stimulate the ovaries. In some cases, doctors may suggest using donor eggs, especially for women of advanced maternal age with very poor reserve.

Lifestyle Factors Affecting Ovarian Reserve

While age is beyond control, lifestyle choices can impact ovarian health and IVF outcomes. Experts recommend:

• Healthy diet: Rich in antioxidants, whole grains, fruits, and vegetables to support egg quality.
• Regular exercise: Moderate activity improves circulation and hormonal balance.
• Avoiding smoking and alcohol: Both accelerate egg loss and harm fertility.
• Weight management: Being underweight or overweight can disrupt hormone levels.
• Stress reduction: High stress can impact hormone production and menstrual cycles.

When to See a Doctor

Couples should seek medical advice if:

• The woman is under 35 and has not conceived after 12 months of trying.
• The woman is over 35 and has not conceived after 6 months of trying.
• There are known reproductive issues such as irregular cycles, PCOS, or endometriosis.
• Previous fertility treatments have failed.

Treatment Options for Low Ovarian Reserve

If tests show diminished ovarian reserve, doctors may recommend:

• IVF with stimulation protocols tailored to the patient.
• Egg freezing for younger women at risk of declining ovarian reserve.
• Donor eggs for women with severely low reserves or poor egg quality.
• Adjunct therapies such as DHEA supplements, Coenzyme Q10, or growth hormone (under medical supervision).

Key Takeaways

• Ovarian reserve reflects both egg quantity and quality, and it is one of the most important factors in fertility.
• Age remains the strongest determinant of ovarian reserve and IVF success.
• AMH testing and other diagnostic tools give doctors valuable insight into fertility potential.
• While ovarian reserve cannot be increased, lifestyle choices and medical treatments can improve outcomes.
• Early evaluation and timely medical consultation give couples the best chance of success with IVF.

Understanding ovarian reserve is a critical step in fertility planning and IVF treatment. Age and AMH levels provide essential insights into a woman’s reproductive potential, guiding doctors in creating the most effective treatment strategies. While women cannot control the natural decline of their eggs, proactive health choices, timely testing, and advanced fertility treatments can help maximize the chances of building a family.