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Delta Infecting Even The Fully Vaccinated At A Greater Rate

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India's First Case of COVID-19 Variant XE Detected in Mumbai Amid Controversy
India's First Case of COVID-19 Variant XE Detected in Mumbai Amid Controversy
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The fattest, fittest and most formidable version of the coronavirus is the Delta variant but there are upending assumptions about the disease even as nations loosen restrictions and open their economies, according to virologists and epidemiologists.

Amid all these vaccine protection remains very strong against severe infections and hospitalisations caused by any version of the virus, and according to leading Covid-19 experts, those who are most at risk are still unvaccinated.

The most dangerous part about the Delta variant is not that it makes people more sick but it spreads far more easily from person to person and this increases the risk of infections and hospitalisations among the unvaccinated. As well as there are evidences that are also increasing that is capable of spreading infection in fully vaccinated people at a greater speed than previous versions, and there have been concerns that they may even spread the virus, said the experts.

Microbiologist Sharon Peacock said,“The biggest risk to the world at the moment is simply Delta.”

Until there is more data on its transmission, according to experts masks, social distancing and other measures are set aside in countries with broad vaccination campaigns may again be needed.

The Pfizer vaccine, one of the most effective against Covid-19 so far that appeared only 41% effective at halting symptomatic infections in Israel over the past month as the Delta variant spread.

Those hospitalised in Britain with the Delta variant, 58.3% were unvaccinated and 22.8% were fully vaccinated said Public Health England. In Singapore, 75% of its cases occurred among vaccinated individuals, where Delta is the most common variant.

Israeli officials said 60% of current hospitalised cases were in vaccinated people.

About 83% of new infections of Delta variant are seen in the US. So far, unvaccinated people represent nearly 97% of severe cases according to reports.

According to a study in China it was found that people infected with the Delta variant carry 1,000 times more virus in their noses compared with the ancestral Wuhan strain.

“You may actually excrete more virus and that’s why it’s more transmissible. That’s still being investigated,” Peacock said.

“It’s outcompeting all other viruses because it just spreads so much more efficiently,” said virologist Shane Crotty.

Genomics expert Eric Topolnoted that Delta infections have a shorter incubation period and a far higher amount of viral particles.

“That’s why the vaccines are going to be challenged. The people who are vaccinated have got to be especially careful. This is a tough one,” Topol told reuters.

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The Nipah virus is considered one of the deadliest zoonotic infections globally, not because it spreads rapidly like influenza or COVID-19, but because of its extremely high fatality rate, rapid progression, and severe brain involvement. Medical experts warn that once symptoms escalate, the disease can turn fatal within days. According to available data, the case fatality rate of Nipah virus ranges between 50 and 75 per cent, placing it among the most lethal viral infections known to humans. In this explainer, Dr Dip Narayan Mukherjee, Consultant – Microbiology and Infectious Diseases, CK Birla Hospitals, CMRI, sheds light on why the virus is so dangerous and difficult to control. Why Is the Nipah Virus So Deadly? According to Dr Mukherjee, Nipah’s lethality lies in a combination of delayed symptom recognition, aggressive disease progression, and early involvement of the brain. “Nipah virus often begins with very non-specific symptoms, which makes early detection difficult. By the time it is clinically suspected, the virus may have already affected the brain,” he explains. Early Symptoms Often Go Unnoticed One of the biggest challenges in controlling Nipah virus is that its initial symptoms closely resemble common viral illnesses, leading to delays in diagnosis and isolation. Early symptoms include: Fever Headache Cough Muscle pain General weakness “These symptoms are easily mistaken for flu, viral fever, or respiratory infections,” says Dr Mukherjee. “This delay gives the virus time to progress silently.” Severe Brain Infection Drives High Mortality The most dangerous aspect of Nipah virus infection is its neurological involvement. The virus frequently causes encephalitis, or inflammation of the brain, which significantly increases the risk of death. Neurological symptoms may include: Seizures Confusion and altered consciousness Extreme drowsiness Coma “Once the central nervous system is involved, the disease becomes very difficult to manage,” Dr Mukherjee notes. “At this stage, treatment is largely supportive because there is no specific antiviral therapy available.” This lack of targeted treatment options makes early detection critical. Human-to-Human Transmission Raises Risk While Nipah virus is primarily transmitted from fruit bats, it can also spread from person to person, particularly in healthcare settings. Dr Mukherjee points out that: Caregivers and healthcare workers are at higher risk Exposure to high viral loads can worsen outcomes Inadequate infection control increases transmission risk “Strict adherence to infection control practices is essential. Even a small lapse can result in secondary infections,” he says. Zoonotic Nature Makes Exposure Hard to Predict Nipah virus is transmitted from fruit bats, either directly or through intermediate hosts such as pigs. This zoonotic pattern makes outbreaks unpredictable, especially in regions where humans, animals, and wildlife interact closely. Adding to the challenge: There is no approved vaccine Treatment options remain limited Isolation protocols must be strictly enforced What Can Reduce Nipah Fatalities? According to experts, early action remains the most effective defence against Nipah virus. Key measures include: Early isolation of suspected cases Strict use of personal protective equipment (PPE) Rapid escalation and referral to specialised centres Strong hospital infection control protocols “The earlier the virus is identified and contained, the better the chances of preventing severe disease and fatalities,” Dr Mukherjee emphasises. The Bottom Line Nipah virus continues to be a serious public health threat because of its high fatality rate, neurological complications, and lack of targeted treatment. Its ability to masquerade as a mild illness in the early stages makes vigilance crucial. Health experts stress that awareness, early suspicion, and strict infection control are currently the most powerful tools to reduce deaths linked to this deadly virus. As Dr Mukherjee concludes, “With Nipah, time is the most critical factor. Early recognition can save lives.”
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