New Delhi, 27 August 2025: Statins are among the most commonly prescribed medications for lowering cholesterol and reducing the risk of heart attacks and strokes. While their benefits are well-documented and they’ve helped millions of people manage heart disease risks, there are side effects that many patients are not told about when starting treatment. Some are rare, others subtle, but all are worth knowing.
Here’s a look at seven statin side effects that your prescription might not have included in fine print — but your body might still notice.
1. Muscle and Joint Discomfort
Mild muscle pain is one of the most reported side effects of statins. While it doesn’t affect everyone, it’s not unusual to feel slight aches, tenderness, or stiffness, especially during physical activity. In most cases, these symptoms are not serious and tend to resolve with time or dosage adjustment. Some patients even experience these effects due to the expectation of harm, not the drug itself. Regardless, any new or persistent discomfort should be discussed with your doctor.
2. Rare Autoimmune Muscle Damage
In very rare cases, statins can trigger a serious condition known as autoimmune myopathy. This condition causes the immune system to attack healthy muscle tissue, leading to ongoing muscle weakness even after the statin is stopped. It typically requires immunosuppressive therapy and specialist care. Though rare, this side effect can be serious and is usually identified through blood tests and muscle biopsies.
3. Digestive Disruptions
Some statin users report mild digestive issues like nausea, bloating, constipation, or diarrhea. These side effects are generally temporary and not severe, but they can still be bothersome. Often, taking the medication with food or changing the time of day it’s taken can help ease digestive discomfort.
4. Memory and Focus Issues
Some individuals on statins report episodes of forgetfulness, confusion, or “brain fog.” These cognitive symptoms are usually mild and reversible once the medication is stopped or changed. The connection between statins and memory problems isn’t fully understood, and these effects don’t occur in most users, but they’re worth noting, especially if you notice changes in your thinking or focus after starting the drug.
5. Liver Enzyme Elevation
Statins can occasionally cause elevations in liver enzyme levels, which are usually picked up during routine blood tests. In most cases, the changes are mild and do not require stopping the medication. However, if you experience unusual fatigue, yellowing of the skin or eyes, or pain in the upper right side of the abdomen, it’s important to get checked. Your doctor may recommend regular monitoring just to be safe.
6. Higher Blood Sugar Levels
Research has shown that statins can cause a slight increase in blood sugar levels. For most people, this isn’t a problem. But for those who are already at risk for type 2 diabetes, statin use may accelerate its onset. Despite this, for people with high cardiovascular risk, the benefits of statins still far outweigh this small increase in diabetes risk. It’s important to monitor blood sugar levels regularly if you’re taking statins long-term.
7. Fatigue, Mood Changes, and Altered Taste
Some users report more unusual side effects, including fatigue, mood changes like irritability or low mood, and changes in taste or smell. These are less common and not well understood, but they have been reported anecdotally. While there’s no conclusive evidence linking statins directly to these symptoms, if you notice unexplained changes after starting the medication, it’s worth bringing them up during a check-up.
What Should You Do if You Notice These Symptoms?
First and foremost: don’t stop taking statins without speaking to your doctor. Many side effects can be managed by adjusting the dosage, switching to a different statin, or adding supplements such as CoQ10 (although evidence on its effectiveness is mixed). In some cases, simply taking the medication at a different time of day can reduce discomfort.
If your symptoms persist or interfere with your quality of life, your doctor may explore other cholesterol-lowering strategies, such as dietary changes, exercise programs, or non-statin medications.
When to Call Your Doctor
You should contact your healthcare provider if you experience:
- Persistent or worsening muscle pain or weakness
- Unusual fatigue or cognitive changes
- Abdominal pain, jaundice, or dark-colored urine
- Blood sugar spikes or symptoms of high blood sugar (increased thirst, frequent urination)
- Emotional changes, mood swings, or new depressive symptoms
These may not be common, but catching them early can help avoid more serious problems.
Statins have proven benefits and are life-saving for many people. However, like any medication, they can come with side effects — some expected, some surprising. Being informed about both the common and uncommon effects allows you to better advocate for your own health.
If you are starting statins or have been on them for a while, it’s smart to pay attention to how your body responds. And if something feels off, don’t ignore it. A conversation with your doctor might lead to simple adjustments that keep both your heart and your overall well-being in check.
